Like many other European countries, Belgium implements policies related to birth, death, and the in-between events that challenge individual space. Biomedical knowledge is one of the resources that define such policies. As pointed by Foucault, biopolicy emerges when the State aims to control the risks that threaten public health. In Belgium, public regulations in three sectors, namely agro-food and GMOs, mobile telephony, and biomedicine (including assisted reproductive technologies, stem cells, and cloning) are so different that it is useful to talk about biopolicies rather than about a single biopolicy. This paper focuses on explaining this variation. Three explanatory factors can help highlight this intriguing form of risk management: agenda setting and thus the social construction of the biopolitical objects to be regulated, the mobilization of social actors regarding these objects, and the types of expertise supporting public decisions.